Dipyridamole Tablets

[Drug Name]
Common name: Dipyridamole Tablets
Product name: Dipyridamole Tablets
Pinyin: Shuangmidamo Pian
Indications for the prevention of thromboembolic disease.
[Specification] 25mg
Dosage orally. A 25 ~ 50mg, 3 times a day, before meals or compliance.
Pharmacology and Toxicology with anti-thrombotic effect. Dipyridamole inhibits platelet aggregation and high concentrations (50 μg / ml) inhibit platelet release. The mechanism may be:

Inhibition of platelet, epithelial cells and erythrocyte uptake of adenosine, the therapeutic concentration (0.5 ~ 1.9μg / dl) when the inhibition in a dose-dependent manner. Local adenosine concentration increased, acting on the platelet A2 receptor, stimulating adenylate cyclase, platelet levels of cyclic adenosine monophosphate (cAMP) increased. Through this pathway, platelet aggregation factor (PAF), collagen and adenosine diphosphate (ADP) and other stimulation of platelet aggregation is inhibited.

Inhibition of phosphodiesterase (PDE) in various tissues. The inhibitory effect of cGMP-PDE on cAMP-PDE was weak, and the concentration of cGMP induced by EDRF was increased.

Inhibition of thromboxane A2 (TXA2) formation, TXA2 is a strong agglutination of platelet activity.

Enhance the role of endogenous PGI2.

Dipyridamole has an effect on blood vessels. Dogs by duodenum given dipyridamole 0.5 ~ 4.0mg / kg dose-related body circulation and coronary vascular resistance decreased, systemic blood pressure and coronary blood flow increased. Twenty-four hours after administration, the effect lasted about 3 hours.
The same hemodynamic effects were observed in humans. However, acute intravenous administration can reduce the localized myocardial perfusion in the distal segment of the stenosis.
18,25 and 75 mg / kg (1,3.1 and 9.4 times the maximum daily recommended dose) of dipyridamole did not produce a significant carcinogenic effect in mice at 111 weeks and in rats from 128 to 142 weeks of oral administration. The results of the mutagenic test were negative. The rat reproductive test uses 60 times the daily maximum recommended dose of dipyridamole, which does not show evidence of reproductive impairment. But at 115 times the maximum daily recommended dose, the number of corpus luteum was significantly reduced, live births decreased. Mice, rats and rabbits did not show evidence of dipyridamole damage to the fetus.
Mice LD50 was 2150 mg / kg; single oral lethal dose was 6000 mg / kg in rats and 350 mg / kg in dogs.
[Packing] solid medicinal plastic bottles, 100 tablets / bottle.